Values of Serum sTNFR-1,sIL-2 Ra and IGF-1 on Depression in Patients with Esophageal Cancer by Nursing Intervention

VernacularTitle:血清sTNFR1，sIL-2Ra和IGF-1在食管癌抑郁患者护理干预中的价值
Author: Minhui WANG ; Qinmei LU ; Yanfei XU
Publication Type:Journal Article
Keywords: comprehensive nursing intervention; esophageal cancer; sTNFR-1; sIL-2Ra; IGF-1
From: Journal of Modern Laboratory Medicine 2014;(6):153-155
CountryChina
Language:Chinese
Abstract: Objective To analyze the clinical value of sTNFR-1,sIL-2Ra and IGF-1 on depression in patients with esophageal cancer by comprehensive nursing intervention and explore the possibility of serum indicators to replace DSI and HAMD. Methods 120 patients with pathologically confirmed esophageal cancer were included in the study.Zung depression status inventory (DSI)and hamilton depression rating scale (HAMD)were used to assess depression.Serum sTNFR-1,sIL-2Ra and IGF-1were detected by enzyme-linked immunosorbent assay (ELISA).Results 69 patients were classified as anxiety and depression group,51 patients were as normal control group.There were 32 patients with depression.Serum sTNFR-1, sIL-2Ra and IGF-1 levels in study group was higher than that in the control group (P<0.05)and these serological indexs increased from the minimal depression,mild-to-moderate depression group to severe depression group (P<0.05).Conclusion Serum sTNFR-1,sIL-2Ra and IGF-1 levels may be used as evaluation index of nursing intervention,but need further clini-cal validation.