Study on Allergen Detection and Immune Molecules in the Patients with Bronchial Asthma
10.3969/j.issn.1671-7414.2014.06.031
- VernacularTitle:支气管哮喘患者变应原检测及免疫分子研究
- Author:
Jianqiu ZHAO
;
Dengfeng WANG
- Publication Type:Journal Article
- Keywords:
bronchial asthma;
allergen;
immune molecules
- From:
Journal of Modern Laboratory Medicine
2014;(6):96-98
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the allergens and study the clinical significance of detecting serum levels of TNF-α,IL-4, IL-6 and IL-8 in patients with bronchial asthma.Methods 62 cases of patients with bronchial asthma were selected from August 2011 to August 2013 in Baoji Central Hospital,enzyme-linked immunosorbent assay were carried out in patients u-sing standardized allergens.62 cases of healthy people were selected as control group,and detected serum levels of TNF-α, IL-4,IL-6 and IL-8 of the two groups.Results Dust mites were the most important and the strongest allergens.The levels of TNF-α,IL-4,IL-6 and IL-8 in observation group was significantly higher than those in control group (230.87±27.82 ng/ml vs 152.14± 23.27 ng/ml;25.32 ± 12.04 ng/L vs 8.57 ± 3.64 ng/L;152.45 ± 24.56 μg/L vs 98.56 ± 18.63 μg/L;218.79±32.91μg/L vs 142.68±23.76μg/L,P<0.05).Conclusion TNF-α,IL-4,IL-6 and IL-8 levels in patients with bronchial asthma j udgment can be used as an important predictor,and it is worthy of clinical application.
