Clinical Significance of Lymphocyte Subsets Change in Breast Cancer Patients before and after Treatment
10.3969/j.issn.1671-7414.2014.06.029
- VernacularTitle:乳腺癌病人淋巴细胞亚群治疗变化及临床意义
- Author:
Rong YUAN
;
Jun LI
;
Yiyu WANG
;
Linqing YAN
;
Ying LIU
- Publication Type:Journal Article
- Keywords:
breast cancer;
operation;
chemotherapy;
lymphocyte subsets;
NK cell
- From:
Journal of Modern Laboratory Medicine
2014;(6):91-93
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the changes of lymphocyte subsets before and after the treatment with operation and chemotherapy in patients with breast cancer.Methods Using cytometer to measure lymphocyte subsets of CD3+,CD4+, CD8+,CD4+/CD8+ and NK of 25 breast cancer patients before and after treatment.The all 25 patients were treated with operation and chemotherapy after pathological diagnosis.The article compared the figures of T cell subsets before and after treatment.Results Compared with before operation and chemotherapy,the CD8+ statistically decreased after 1~3 months of treatment (t=2.57),and NK statistically increased after 3~6 (t=-2.23).After 6 months of treatment,the patients’ CD3+(t=-2.25),CD4+(t=-2.07)were statistically lower and NK (t=-3.56)was statistically higher.There was no significant difference for other items.Conclusion Lymphocyte subsets test against breast cancer patients can reflect immuni-ty level at a certain level during treatment.But how to explain the figures in different stage against treatment effectiveness and prognosis need further research.
