Research Status of GRP7 8
10.3969/j.issn.1671-7414.2014.06.002
- VernacularTitle:GRP78研究新进展
- Author:
Xin ZHANG
;
Yuming WANG
;
Yong DUAN
- Publication Type:Journal Article
- Keywords:
GRP78;
ER-stress;
tumor;
viral infectious disease;
research prospects
- From:
Journal of Modern Laboratory Medicine
2014;(6):5-8
- CountryChina
- Language:Chinese
-
Abstract:
GRP78/Bip,which was first identified by scientists in 1977,is a major endoplasmic reticulum (ER)chaperone that has a variety of function.In tumor tissue,GRP78 is high expression and ectopic expression;participate in the development of tumor,ER-stress state and ectopic distribution on the cell surface,in the form of receptors involved in signal transduction. Therefore,GRP78 as an tumor therapeutic targets,biomarkers of tumor and prognosis of tumor biological markers,plays an important role in the tumor research.In recent years,domestic and foreign scholars have found that in the non-cancer disease (viral infectious disease cardiovascular disease diabetes neurodegenerative disease etc),GRP78 is high expression,indicate its application prospect.This article makes a brief overview on the molecular biological characteristics of GRP78,role in tumor pathogenesis and therapeutic significance and application prospect in non-tumor disease.
