Comparative Study on Allograft Functions of HLA Antibody in Patients Who Received Pairs of Allograft from the Same Donor
10.3969/j.issn.1671-7414.2014.05.038
- VernacularTitle:同一供肾者移植成对患者抗HLA抗体对肾功能的对比研究
- Author:
Baoxiang JIA
;
Dong ZHANG
;
Xiuhong XU
;
Junjie WU
;
Weiran MA
- Publication Type:Journal Article
- Keywords:
renal transplant;
same donor;
HLA antibody;
renal function
- From:
Journal of Modern Laboratory Medicine
2014;(5):138-140
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the influence on allograft function of HLA antibody in patients who received pairs of allograft from the same donor.Methods In Beijing Friendship Hospital.HLA antibodies were tested from October,2008 to April 2009 in patients.Recently (October,2013-February,2014),renal functions(serum creatinine/urea nitrogen)were studied in 226 patients who received transplant from 113 donors.LATM10x5,One Lambdas used for Panel reactive antibody screen-ing.Results 41 pairs of renal for male,21 pairs of renal for female and 51 pairs of renal for both male and female.PRA posi-tive in 26 patients (only 4 pairs of renal for patients were positive),11 recipients (HLA II antibody positive in only 1 pair of renal for patients)and 36 recipients (only 5 patients produced antibody)in 226 patients,HLA antibody positive in 73 pa-tients,in which renal function lost or decreased in 64 patients.HLA antibody negative in 153 recipients,in which renal func-tion lost or decreased in 4 patients.There was significant difference between the two group (χ2=160.70,P<0.001).Con-clusion HLA antibody is a important factor influence renal function and long term survival.
