Application Study on the Combined Detection of Serum HCY and Liver Function Indicators in Liver Disease Diagnosis
10.3969/j.issn.1671-7414.2014.05.036
- VernacularTitle:血清HCY与肝功能指标联合检测在肝病诊断中的应用研究
- Author:
Futang YAN
;
Hua ZHANG
;
Jun YUAN
;
Xiaoli LU
;
Shuling HU
;
Juan MA
;
Xiao ZHENG
- Publication Type:Journal Article
- Keywords:
homocysteine(HCY);
chronic active hepatitis;
cirrhosis;
primary hepatic cancer;
combined detection
- From:
Journal of Modern Laboratory Medicine
2014;(5):132-134
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the serum homocysteine (HCY)levels of patients with various liver diseases,and discuss the clinical value of combined detection of HCY and other liver function indicators in liver disease diagnosis.Methods Se-lected 123 cases of inpatients with different liver diseases (79 cases of male,44 cases of female),including 39 cases of chronic active hepatitis,52 cases of cirrhosis and 32 cases of primary hepatic cancer from Department of Gastroenterology,and 90 ca-ses of healthy persons as control group from Out-patient Health Examination Center of Shaanxi Provincial People’s Hospi-tal.Detected serum HCY and some indicators of liver function (TBIL,ALT,GGT and TBA)in different liver disease groups and normal control group with Roche MODUALR automatic biochemical analyzer,and did statistic analysis.Results The serum HCY levels of chronic active hepatitis,liver cirrhosis and primary hepatic cancer were 16.25± 3.98μmol/L,20.89± 4.26μmol/L and 22.92 ± 6.08μmol/L respectively,and significantly higher than those in normal control group (8.16 ± 4.03μmol/L,t=5.352~9.021,P<0.01).The serum HCY levels of liver cirrhosis and primary hepatic cancer group were higher than that of chronic active hepatitis group (P<0.05).Serum levels of HCY were obviously lower after treatment than that before treatment (P<0.05)for three groups of liver diseases.The positive rate of HCY was higher than those of other liver function indicators (P<0.05).Conclusion Serum homocysteine may be as one of the most important indexes of liver damage,and the combined detection of other liver function indicators may have important clinical value for liver disease diagnosis,differential diagnosis,treatment and prognosis.
