Comparison of TB-IGRA and Protein Chip in the Diagnosis of Mycobacterium Tuberculosis
10.3969/j.issn.1671-7414.2014.05.030
- VernacularTitle:干扰素释放酶联免疫法（TB-IGRA）与蛋白芯片法检测结核分枝杆菌的方法比较
- Author:
Qiaodi GUI
;
Ke LIU
;
Jinrong CANG
;
Yanyan GONG
;
Ying LIU
;
Miao CHEN
;
Yan LI
;
Jie SONG
;
Jiankang REN
- Publication Type:Journal Article
- Keywords:
TB-IGRA;
protein chip;
Mycobacteriumtuberculosis
- From:
Journal of Modern Laboratory Medicine
2014;(5):114-116
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the advantages of TB-IGRA and protein chip to detect the Mycobacterium tuberculosis. Methods From October 2013 to March 2014,collected 78 cases of clinical diagnosis of tuberculosis and normal control’s pe-ripheral blood specimens,used TB-IGRA kits and Mycobacteriumtuberculosis IgG kit(protein chip)to detected respectively. The results were analyzed and compared.Results The sensitivity of protein chip and TB-IGRA in the detection of Mycobac-teriumtuberculosis were 34.5% and 89.7% respectively,which was statistically significant (χ2=26.95,P<0.05).The spe-cificity of protein chip and TB-IGRA were 90.0%,95.0% respectively,which were not statistically significant (χ2=1.64,P> 0.05).The positive rate of TB-IGRA and Protein chip in tuberculosis were 90.5% and 42.9%.The positive rate of TB-IGRA and Protein chipin extrapulmonary tuberculosis were 89.20% and 29.7% respectively.Conclusion Compared TB-IGRA and protein chip,either diagnose tuberculosis or extrapulmonary tuberculosis has highly positive rate and sensitivity, TB-IGRA can be widely used in the early screening of tuberculosis.
