Meta-Analysis on Interleuki-1 0 Polymorphisms and Endometriosis Susceptibility
10.3969/j.issn.1671-7414.2014.05.022
- VernacularTitle:白细胞介素-10基因多态性与子宫内膜异位症易感性关系的Meta分析
- Author:
Jinghua SUN
;
Xu CHEN
;
Xiandu SU
;
Changling FAN
;
Hai WANG
;
Chengbin WANG
;
Jian LI
- Publication Type:Journal Article
- Keywords:
endometriosis;
interleukin-10;
polymorphism;
meta-analysis
- From:
Journal of Modern Laboratory Medicine
2014;(5):89-92
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the association between interleukin-10(IL-10 )polymorphisms and endometriosis suscepti-bility by meta-analysis.Methods Computer retrieval Pubmed,Embase,Chinese HowNet,Chinese biomedical and Wanfang database.Published data relating to case-control studies reporting the link between IL-10 polymorph-isms and endometriosis were retrieved.Meta-analysis was conducted to determine whether the IL-10 gene polymorphisms were associated with endo-metriosis.Results Six studies were finally accepted for analysis.There were five studies focused on-819T/C polymorphism and six studies focused on-592A/C polymorphism.The odds ratio of each genetype for endometriosis:TT/CC,TC/CC,AA/CC and AC/CC were 0.90(0.81~0.99),P<0.05;0.92(0.82~1.02),P>0.05;0.92(0.79~1.07),P>0.05;0.98(0.90~1.06),P>0.05.No significant publication bias was found regarding TT/CC,TC/CC,AA/CC and AC/CC genotypes(P=0.81,0.81,0.71,0.26).Conclusion IL-10 gene-819TT genotypes may be a protetive factor of endometriosis.There was no related to show that other genotypes in position-819 and-592 were associated with endometriosis.