The role of nuclear factor-κB pathway on carcinogenesis and therapy of thyroid cancer
10.3760/cma.j.issn.2095-2848.2014.05.021
- VernacularTitle:核因子-κB通路在甲状腺癌发生机制和治疗中的作用
- Author:
Zhaowei MENG
;
Qiang JIA
;
Jian TAN
- Publication Type:Journal Article
- Keywords:
Thyroid neoplasms;
Nuclear factor-kappa B;
Trends
- From:
Chinese Journal of Nuclear Medicine and Molecular Imaging
2014;34(5):415-418
- CountryChina
- Language:Chinese
-
Abstract:
The incidence rate of thyroid cancer is increasing very rapidly during the past years.131I treatment for DTC is an effective method.However,DTC refractory to 131I treatment or therapeutic failure is not uncommon.High level expression of nuclear factor-kappa B (NF-λB) in thyroid cancer is closely related with carcinogenesis,progression,anti-apoptosis and therapeutic resistance.NF-κB inhibitor was effective for the treatment of thyroid cancer.Combined NF-κB inhibitor with131I may improve the therapeutic efficacy.
