Effect of Ulinastatin on T-cytoimmunity in patients with infetility undergoing laparoscopic surgery
10.3969/j.issn.1006-5725.2015.13.003
- VernacularTitle:乌司他丁对腹腔镜妇科不孕症手术患者T淋巴细胞免疫功能的影响
- Author:
Lian DENG
;
Zurong HU
;
Jing YI
;
Danchen SU
;
Chengyi CAI
- Publication Type:Journal Article
- Keywords:
Ulinastatin;
Laparoscopy;
Immunity;
T-lymphocyte
- From:
The Journal of Practical Medicine
2015;(13):2081-2083
- CountryChina
- Language:Chinese
-
Abstract:
Objective To research the effect of ulinastatin on T-cytoimmunity in patients with infertility undergoing laparoscopic surgery. Methods Forty patients scheduled for receiving laparoscopic surgery were equally randomized into two groups, ulinastatin group (Group U) and control group (Group C). Ulinastatin was given to patients in the Group U at a dose of 20 × 104 U before anesthetic. No ulinastatin was given to patients in the Group C. Patients′venous blood samples for T-lymphocyte subset (CD3+,CD3+CD4+,CD3+CD8+) and CD3+CD4+/ CD3+CD8+ ratio calculation were collected before the surgery (T0) and at 0 h (T1),1st day (T2),3rd day (T3) after the surgery. Results CD3+ had less difference at T1~3 compared with T0 in the Group C but raised obviously at T2~3 in the Group U. CD3+CD4+ were only raised at T3 compared with T0 but raised obviously at T2~3 in the Group U. CD3+CD8+ were raised obviously at T2~3 compared with T0 in the Group C but had less difference in the Group U. CD3+CD4+/CD3+CD8+ had less difference at T1~3 compared with T0 in the Group C but raised obviously at T3 in the Group U. Conclusion The application of ulinastatin in laparoscopic surgery could significantly produce protective effect on T-cytoimmunity.
