Effect of dexmedetomidine on patients′ inflammation during the CPB and the effect on patients′ renal and hepatic function
10.3969/j.issn.1006-5725.2015.13.005
- VernacularTitle:右美托咪定对体外循环围术期炎症因子的影响及其对肝肾功能的保护作用
- Author:
Jun QIN
;
Zaisheng QIN
;
Chen ZHU
;
Linlin LIU
;
Tao TAO
- Publication Type:Journal Article
- Keywords:
Dexmedetomidine;
HMGB-1;
TNF-α;
IL-6;
CPB
- From:
The Journal of Practical Medicine
2015;(13):2087-2089
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the effect of dexmedetomidine on patients′ inflammation during CPB and protective effect on kidney and liver. Methods 60 cases undergoing cardiac valve replacement under CPB were randomly divided into NS group and Dex group. Blood samples were taken before induction , before ascending aorta blocked, end of CPB, 24, 48 and 72 hours after operation. The serum level of HMGB-1, TNF-α, IL-6, BUN, Cr and ALT are tested. Blood WBC and N% are also counted. Results WBC, N% and HMGB-1, TNF-α, IL-6, BUN, Cr in Dex group significantly decreased at time point T2 ~ T6 (P < 0.05) compared with NS group. But ALT in Dex group only decreased at time point T 2 and T5 compared with NS group (P < 0.05). Conclusion Dexmedetomidine can significantly decrease inflammatory factor during CPB and improve renal function after surgery.
