Research progress of hematopoietic stem cells location and its interaction with surrounding microenvironment
10.3760/cma.j.issn.1009-9921.2014.11.016
- VernacularTitle:造血干细胞定位及其与周围微环境相互作用的研究进展
- Author:
Yanyan YE
- Publication Type:Journal Article
- Keywords:
Hematopoietic stem cells;
Transplantation;
Homing;
Bone marrow microenvironment
- From:
Journal of Leukemia & Lymphoma
2014;23(11):700-702
- CountryChina
- Language:Chinese
-
Abstract:
Homing and engraftment of transplanted hematopoietic stem cells (HSCs) can directly influence the effect of the transplantation.Exploration on its spatial distribution,location and interaction with the bone marrow (BM) microenvironment is great significance.Since the BM cavity is closed and surrounded by thick compact bone,it makes a colossal challenge to track the transplanted HSCs in vivo directly.Recently,researchers used different innovative methods to observe the spatial distribution and interaction with the BM microenvironment of the transplanted HSCs.The present review summarized the progress in the HSCs transplantation.
