Study on the relationship of insulin resistance and early renal injury with genetic factor in the healthy offspring with a family history of essential hypertension
10.3760/cma.j.issn.0254-9026.2015.06.016
- VernacularTitle:具有原发性高血压遗传史的健康子女胰岛素抵抗及早期肾损害与遗传因素关系的研究
- Author:
Hua LIU
;
Na LIN
- Publication Type:Journal Article
- Keywords:
Hypertension;
Genetic predisposition to disease;
Renal failure,chronic;
Insulin resistance
- From:
Chinese Journal of Geriatrics
2015;34(6):638-640
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the insulin resistance and microalbuminuria in the healthy offspring with a family history of essential hypertension,in order to explore the relationship between the genetic factor and early renal injury.Methods 69 healthy offsprings with the family history of essential hypertension were randomly recruited as the observation group,35 healthy offsprings without the family history of essential hypertension were considered as the control group.The consecutive 12-hour urine was collected to detect the urinary albumin,and blood biochemical examination was conducted.Results Plasma levels of triglyceride (TG),total cholesterol (TC),glucose,fasting insulin,and urinary albumin excretion rate were higher in observation group than in the control group [(1.07±0.65) mmol/L vs.(0.79±0.52) mmol/L,(4.83±0.78) mmol/L vs.(4.48±0.63) mmol/L,(5.27±0.73) mmol/L vs.(4.94±0.85) mmol/L,(10.63±3.21) mIU/L vs.(7.72±3.35) mIU/L,(45.6±29.5) μg/min vs.(18.6±11.7) μg/min,t=2.259、2.348、2.093、4.381、5.337,all P＜0.05].Conclusions Insulin resistance and microalbuminuria occur before hypertension in healthy offsprings with the family history of essential hypertension,and the patients are prone to getting early renal damage,which indicates that heredity is a risk factor for chronic kidney disease.
