Clinical observation of tirofiban for emergency interventional therapy in patients with acute ST segment elevation myocardial infarction
10.3760/cma.j.issn.1673-4904.2014.31.008
- VernacularTitle:急诊介入治疗急性ST段抬高型心肌梗死应用替罗非班的临床观察
- Author:
Hua TANG
;
Guang FU
;
Shubin HUANG
;
Lixia MA
- Publication Type:Journal Article
- Keywords:
Myocardial infarction;
Electrocardiography;
Coronary circulation;
Interventional therapy;
Tirofiban
- From:
Chinese Journal of Postgraduates of Medicine
2014;37(31):22-24
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the efficacy and safety of tirofiban for emergency interventional therapy in patients with acute ST segment elevation myocardial infarction.Methods The 96 acute ST segment elevation myocardial infarction patients having accepted emergency percutaneous coronary intervention (PCI) were divided into treatment group and control group according to the treatment method with 48 cases each.The treatment group was given conventional standard treatment combined with tirofiban treatment [tirofiban intracoronary injection 10 μ g/kg and then intravenous 0.15 μ g/(kg· min) for 24-48 h].The control group was given conventional standard treatment only.The postoperative 60 min electrocardiogram ST segment recovery,the coronary blood flow TIMI grade,the major adverse cardiac events (angina,myocardial infarction,heart failure,death) and postoperative bleeding in 4 weeks were compared between the two groups.Results The patients having postoperative 60 min electrocardiogram ST segment recovery in treatment group was 45 cases (93.8％,45/48),in control group was 35 cases (72.9％,35/48),and there was statistical difference (P ＜ 0.05).The incidence rate of infarction vascular TIMI grade ≥ 3 grade flow in treatment group was 95.8％ (46/48),in control group was 75.0％ (36/48),and there was statistical difference (P ＜ 0.05).The incidence rate of the major adverse cardiac events 4 weeks in treatment group was significantly lower than that in control group,and there was statistical difference (P ＜ 0.05).There was no statistical difference in the incidence rate of bleeding between the two groups (P ＞ 0.05).Conclusion In patients with acute ST segment elevation myocardial infarction,the emergency interventional therapy with tirofiban is efficacy and safety.
