Influence of calcitriol in pancreatic islet β-cell function and glucose and lipid metabolism in patients with type 2 diabetic mellitus
10.3760/cma.j.issn.1673-4904.2014.31.003
- VernacularTitle:骨化三醇对2型糖尿病患者胰岛β细胞功能及糖脂代谢的影响
- Author:
Jianmin ZHOU
- Publication Type:Journal Article
- Keywords:
Calcitriol;
Diabetes mellitus,type 2;
Insulin resistance
- From:
Chinese Journal of Postgraduates of Medicine
2014;37(31):7-9
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the influence of calcitriol in pancreatic islet β-cell function,blood glucose and blood lipids in patients with type 2 diabetes mellitus.Methods Ninety type 2 diabetes mellitus patients who had been treated with oral medications and whose treatment regimen was relatively stable were divided into calcitriol group (0.25 μ g/d) and control group (placebo) according to the treatment methods with 45 cases each,and all the patients were completed 12-week' clinical observation.Results After treatment compared with before treatment in calcitriol group,fasting plasma glucose (FPG),fasting insulin (FINS),homeostatic model assessment insulin resistance index (HOMA-IR),glycated hemoglobin (HbA1c),total cholesterol (TC),triglyceride (TG),and low density lipoprotein cholesterol (LDL-C) levels were significantly decreased,high density lipoprotein cholesterol (HDL-C) was significantly higher,and there were statistical differences (P ＜ 0.05).While there were no statistical differences in control group between before treatment and after treatment (P ＞ 0.05).Conclusion Calcitriol can improve glucose and lipid metabolism and pancreatic islet β-cell function in patients with type 2 diabetic mellitus and reduce insulin resistance.
