Clinical-pathological characteristics and correlation analysis of gastrointestinal stromal tumor
10.3969/j.issn.1005-6483.2014.10.008
- VernacularTitle:胃肠间质瘤临床病理特点及其相关性分析
- Author:
Ming LUO
;
Xuejun WANG
;
Lanlan CAI
- Publication Type:Journal Article
- Keywords:
gastrointestinal stromal tumor;
clinical characteristics;
surgical treatment
- From:
Journal of Clinical Surgery
2014;(10):738-741
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the clinicalpathological characteristics,surgical treatment andprognosis of the gastrointestinal stromal tumor(GIST).Methods The clinical data of 160 cases of pathologically confirmed GIST were retrospectively reviewed.Clinical features,pathological characteristics andimmune markers were studied by multiple factor analysis.Results There were no intraoperative or deathsin 140 patients who underwent radical resection.Univariate analysis of survival revealed significant differences in the main tumor pathological characteristics,including mitotic figure and metastasis and Fletcher'sclassification(P <0.05).Immunohistochemical results showed that the positive rates of KIA and CD133were 97.6% and 81.3% respectively,and their influences to survival prognosis were of statistical significance(P <0.05).A total of 145(90.6%)patients finished the follow up and 53 cases of them had multiple liver metastasis.These patients received imatinib mesylate(400 mg/d)and the efficacy was significant(P <0.05).Multivariate regression analysis showed that Fletcher's classification and imatinib mesylatewere the independent risk factors affecting prognosis.Conclusion Fletcher's classification is an effectivemethod for evaluating the prognosis of GIST.Radical resection and imatinib mesylate can reach a remarkable curative effect in treating original and metastatic lesions of the GIST patients.
