Effect of Pomegranate Tannins on Endogenous Metabolites in Rat Urine
- VernacularTitle:石榴皮鞣质对大鼠尿液内源性物质代谢的影响
- Author:
Benhong ZHOU
;
Miaomiao LIU
;
Xianxi GUO
;
Jie TU
;
Yue WU
;
Yi LUO
;
Gang LIU
- Publication Type:Journal Article
- Keywords:
Pomegranatetannins;
Administrationtime;
Principalcomponentanalysis;
Partialleastsquares-discriminateanalysis
- From:
China Pharmacist
2014;(10):1609-1612
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To study the influence of pomegranate tannins on the endogenous metabolites in the urine of normal rats by metabonomics method. Methods:The rats were divided into two groups, the blank control group and tannins group. The rats in tan-nins group were orally administered 78. 5 mg·ml-1 pomegranate tannins for 4 weeks. The urine samples were collected and used in the metabonomics study. The urine data were collected by HPLC-MS and comparatively analyzed using PCA and PLS-DA method in SIM-CA-P software. Results:The score points of tannins group displayed obvious distance compared with those of the blank control group, and the changes were the most obvious on the 22nd administration day. Conclusion:Endogenous metabolites in rat urine are obviously influenced by pomegranate tannins, and the research provides the basis for the further study of pomegranate tannins.
