Anti-inflammatory and Analgesic Effects of Different Extracts of Folium Pyrrosiae
- VernacularTitle:石韦不同提取物的抗炎镇痛作用考察
- Author:
Yunda LI
;
Tao HUANG
;
Zudi YAN
;
Zhaoping ZHANG
;
Yuanhui LI
;
Zhongli MA
;
Shanmin ZHAO
- Publication Type:Journal Article
- Keywords:
Folium Pyrrosiae;
Different extracts;
Anti-inflammation;
Analgesia
- From:
China Pharmacist
2014;(10):1642-1644
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To study the anti-inflammatory and analgesic effects of different solvent extracts of Folium Pyrrosiae. Meth-ods:Water extract and 75% alcohol extract of Folium Pyrrosiae were obtained. Mouse auricle swelling model induced by xylene was used to observe the anti-inflammation. The analgesic effect was tested by acetic acid writhing test and hot plate test. Results:The eth-anol extract of Folium Pyrrosiae could markedly inhibit the mouse auricle swelling induced by xylene (P<0. 01), and had the ability to inhibit the twisting induced by acetic acid in the mice (P <0. 05). The ethanol extract of Folium Pyrrosiae could increase the threshold of pain in the mice significantly after the 1-hour and 2-hour treatment (P<0. 05). The water extract of Folium Pyrrosiae could inhibit the mouse auricle swelling induced by xylene and the writhing reaction induced by acetic acid (P<0. 05). The water ex-tract of Folium Pyrrosiae could increase the threshold of pain in the mice significantly after the 1-hour treatment (P<0. 05). Conclu-sion:Folium Pyrrosiae has obvious analgesic and anti-inflammatory effects.
