Enteral nutrition with omega-3 polyunsaturated fatty acid in acute respiratory distress syndrome
10.3760/cma.j.issn.1673-4912.2014.12.004
- VernacularTitle:ω-3多不饱和脂肪酸肠内营养治疗急性呼吸窘迫综合征
- Author:
Hongjun MIAO
- Publication Type:Journal Article
- Keywords:
Omega-3 polyunsaturated fatty acid;
Enteral nutrition;
Acute respiratory distress syndrome
- From:
Chinese Pediatric Emergency Medicine
2014;21(12):760-763
- CountryChina
- Language:Chinese
-
Abstract:
Acute respiratory distress syndrome (ARDS) is a common clinical critical disease threatening patient's life,inflammation caused by diffuse alveolar damage is the essence.Omega-3 polyunsaturated fatty acid(ω-3PUFAs) can inhibit inflammation by decreasing arachidonic acid metabolites through competing with arachidonic acid by a variety of ways,by changing the nature of cell membrane signal platform lipid rafts,by involving in inflammation regression and tissue repairment using its metabolites,by reducing the activation of nulear factors-κB and inhibiting the release of inflammatory mediators in local lung tissue.So,ω-3PUFAs has become the research hot spot in ARDS drug treatment.The clinical study on ω-3PUFAs enteral nutrition in the treatment of ARDS has not yet reached the consistent conclusion,therefore,the multicenter randomized controlled trial is needed.
