Research progress on regulatory mechanism of liver cancer stem cells
10.3760/cma.j.issn.1007-8118.2014.12.019
- VernacularTitle:肝癌干细胞调控机制的研究进展
- Author:
Xu WANG
;
Chao WANG
- Publication Type:Journal Article
- Keywords:
Liver cancer stem cells;
Hepatocellular carcinoma;
Signal transduction;
Epigenetics
- From:
Chinese Journal of Hepatobiliary Surgery
2014;20(12):900-904
- CountryChina
- Language:Chinese
-
Abstract:
The theory of cancer stem cells proposed that recurrence and metastasis of liver cancer are closely related to liver cancer stem cells.The traditional surgical treatment of liver cancer simply kills those rapidly proliferating tunor cells instead of eliminating hepatic cancer stem cells which play decisive role in recurrence and metastasis.As far as people have concerned,there are many signaling pathways and regulatory factors modulating liver cancer stem cells,such as the Wnt/β-catenin pathway,TGF-β pathway,Notch pathway,Hedgehog pathway,hepatitis B virus,as well as epigenetics.Further studies on regulatory mechanisms of liver cancer stem cells are of great significance,in hope of providing new evidence for treatment and prevention of recurrence and metastasis of liver cancer.
