The clinical pathology analysis of papillary thyroid microcarcinoma with clinically node-negative sides of neck stage lymph node metastasis
10.3760/cma.j.issn.1673-4904.2014.29.020
- VernacularTitle:颈侧淋巴结阴性甲状腺乳头状微小癌中央区淋巴结转移临床病理分析
- Author:
Xiaowei GUO
;
Yong LIANG
;
Mingming QUAN
- Publication Type:Journal Article
- Keywords:
Thyroid;
Microcarcinoma;
Central lymph node dissection;
Gene mutation
- From:
Chinese Journal of Postgraduates of Medicine
2014;37(29):60-62
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the clinical pathological factors of papillary thyroid microcarcinoma (PTMC) with clinically node-negative sides of neck stage central lymph node metastasis.Methods Analysis of 136 cases of cNo stage of PTMC of clinical and pathological data,and using the PCR method for the detection of BRAFV600E mutation in the paraffin coated tissue.Results One hundred and thirty-six cases with PTMC lymph node metastasis rate was 38.2％ (52/136),BRAFV600E mutation rate was 44.9％ (61/136).Single factor analysis showed that the lymph node metastasis was related with BRAFV600E mutation and capsular invasion (P＜ 0.05).The size of the tumor was close to significant level (P=0.057).Multiple regression analysis showed that BRAFV600E mutation and capsular invasion were independent factors for affecting the central lymph node metastasis (P ＜ 0.05).Conclusion The routine central lymph node dissection should be performed in patients with BRAFV600E mutation and tumor invasion.
