Research progress of epigenetics in B cell lymphoma
10.3760/cma.j.issn.1009-9921.2015.05.020
- VernacularTitle:B细胞淋巴瘤表观遗传学研究进展
- Author:
Yanyan ZHANG
;
Bo GAO
- Publication Type:Journal Article
- Keywords:
B-cell lymphoma;
DNA methylation;
Histone modification;
MicroRNA
- From:
Journal of Leukemia & Lymphoma
2015;24(5):317-320
- CountryChina
- Language:Chinese
-
Abstract:
As an important component of functional genomics,epigenetics is a subdiscipline within genetics and refers to heritable changes in gene expression without any alteration in DNA sequence,including DNA methylation,histone modification,chromatin remodeling and microRNA (miRNA).Epigenetic regulation plays a crucial role on the development of B-cell lymphomas,as it has been reported that perturbation of epigenetic pattern and mutations in epigenetic mechanisms are frequent events in B-cell lymphomas.This review summarized the research progress on DNA methylation,histone modification and miRNA as well as their roles in the development,treatment and prognosis of B-cell lymphomas.
