Clinical evaluation of multimodality analgesia for patients undergoing radical resection of colon cancer
10.3760/cma.j.issn.1673-4904.2014.29.019
- VernacularTitle:多模式镇痛应用于结肠癌根治术后患者的临床研究
- Author:
Xiaoping DONG
- Publication Type:Journal Article
- Keywords:
Colonic neoplasms;
Multimodality analgesia;
Analgesia efficacy;
Radical operation
- From:
Chinese Journal of Postgraduates of Medicine
2014;37(29):57-59
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the efficacy and safety of multimodality analgesia for patients undergoing radical resection of colon cancer.Methods Seventy patients aged 46-75 years old,undergoing the radical resection of colon cancer were divided randomly into two groups:the trial group (parecoxib preemptive analgesia and ropivacaine local analgesia combined with sufentanil patient-controlled intravenous analgesia) and the control group (sufentanil patient-controlled intravenous analgesia only),each group of 35 patients.The visual analogue scale (VAS) and the usage amount of sufentanil were recorded at 12,24,48 h after operation.The number of unsatisfied demand and the number of successfully delivered doses,sufentanil consumption at 12 h and 24 h after operation,the patients' global evaluation of the postoperative analgesia and adverse effects related to analgesia were recorded and compared between the two groups.Results The VAS scores at 12,24 h after operation in trial group were lower than those in control group [(3.1 ± 1.0) scores vs.(4.0 ± 1.3) scores,(2.8 ± 1.4) scores vs.(3.7 ± 1.2) scores].The degree of satisfaction in trial group was higher than that in control group(P ＜ 0.05).The demand and the number of successfully delivered doses and the usage amount of sufentanil in trail group were significantly lower than those in control group (P ＜ 0.05).The incidence of respiratory depression,nausea and vomitting in trial group were significantly lower than those in control group[0 vs.5.7％(2/35),2.9％(1/35) vs.11.4％ (4/35)] (P ＜ 0.05).Conclusion Multimodality analgesia may have the good analgesic effect in the patients undergoing radical resection of colon cancer,and with fewer adverse events.
