Optimization of β-Cyclodextrin Inclusion Process for Volatile Oil in Yingxinning Capsules by Orthogonal Test
- VernacularTitle:正交试验法优选营心宁胶囊挥发油β-环糊精包合工艺
- Author:
Wei WANG
;
Yan ZHOU
;
Yanbo FAN
;
Qiwei YAN
;
Caixin ZHOU
- Publication Type:Journal Article
- Keywords:
Yingxinningcapsules;
Volatileoil;
β-Cyclodextrin;
Clathrates;
Orthogonaltest
- From:
China Pharmacist
2014;(10):1680-1681
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To optimize β-cyclodextrin (β-CD) inclusion process for volatile oil in Yingxinning capsules. Methods:The content of volatile oil in theβ-CD inclusion compound as the evaluation index, the ratio of volatile oil toβ-CD, inclusion tempera-ture, inclusion time and stirring speed as the influencing factors, the inclusion process was studied using L9(34)orthogonal design. Re-sults:The best preparation conditions were as follows:the ratio of volatile oil toβ-CD was 1∶ 9, the inclusion temperature was 40℃, the inclusion time was 30min and the stirring speed was 800 r·min-1 . Conclusion: The preparation technology is simple, feasible and stable with high inclusion rate of volatile oil.
