Clinical Characters Analysis of Patients with Drug-induced Liver Injury Combined with Hepatitis B
- VernacularTitle:药物性肝损伤合并乙型病毒性肝炎患者的临床特点分析
- Author:
Ying ZHU
;
Ping WANG
;
Tao YIN
- Publication Type:Journal Article
- Keywords:
Drug-inducedliverinjury;
HepatitisB;
Clinicalcharacters;
Retrospectiveanalysis
- From:
China Pharmacist
2014;(10):1702-1704
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To analyze the clinical features of the patients with drug-induced liver injury ( DILI) combined with hepati-tis B to improve the awareness and attention to the disease by medical workers. Methods:Using retrospective analysis, the patients di-agnosed with DILI combined with hepatitis B from a tertiary-hospital were analyzed from January 2013 to January 2014. Results:Total-ly 30 cases of DILI combined with hepatitis B were collected, the number of male patients was higher than that of female patients, and most of them were elderly patients. The symptoms included weak, anorexia, yellow skin and sclera, tired of the oil, nausea, abdominal distension and so on. The patients with severe liver damage accounted for 80. 0%, 16. 7% was with moderate liver damage, and 3. 3%was with mild liver damage. Thirteen cases were mixed type, ten cases were hepatocellular type, and seven cases were cholestatic type. Conclusion:Middle-aged men may be prone to the disease, and the clinical manifestations are complex and diverse. Severe liver damage is majority, and often shows as mixed liver injury.
