Study on Cytotoxicity of Codeine Phosphate Tablets
- VernacularTitle:磷酸可待因片的细胞毒性研究
- Author:
Jiehu OUYANG
;
Xianxian PENG
;
Ruilian LI
- Publication Type:Journal Article
- Keywords:
Codeinephosphatetablets;
Cytotoxicity;
Excipients
- From:
China Pharmacist
2014;(10):1763-1764
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To compare the formula of codeine phosphate tablets produced by two enterprises. Methods: IC50 of the tablets and raw material of codeine phosphate, and the excipients from two enterprises was detected respectively. Results:IC50 of the tablets from A enterprise was 0. 169 mg·ml-1 , that from B enterprise was 0. 140 mg·ml-1 , and the difference was statistically sig-nificant(P<0. 05). IC50 of the raw material from the two enterprises showed no notable difference (P>0. 05). Conclusion: The difference in cytotoxicity of codeine phosphate tablets is manly induced by the excipients, and the products from A enterprise are better than those from B enterprise.
