Research progress of allogeneic stem cell transplantation in multiple myeloma patients

VernacularTitle:异基因造血干细胞移植治疗多发性骨髓瘤研究进展
Author: Huan GUO
Publication Type:Journal Article
Keywords: Allogeneic stem cell transplantation; Multiple myeloma; Graft versus myeloma effect; Graft versus host disease
From: Journal of Leukemia & Lymphoma 2014;23(5):311-314
CountryChina
Language:Chinese
Abstract: Allogeneic stem cell transplantation (allo-HSCT) is probably the only treatment for multiple myeloma (MM) with a curative potential.However,the application of allo-HSCT is limited by the high transplant-related mortality (TRM).Although the introduction of reduced intensity conditioning (RIC) has lowered the TRM associated with myeloablative conditioning,there is no improvement in survival of allo-RIC compared to autologous stem cell transplantation (auto-HSCT).New strategies are discussed with the aim of lowering transplant toxicity and boosting the graft-versus-myeloma effect,and these are urgently needed to make allo-RIC safer and more effective for myeloma patients.In this review,results from studies of allo-HSCT in MM are presented.