Progress of TGR5 receptors in liver metabolism and immune
10.3760/cma.j.issn.1007-8118.2014.11.019
- VernacularTitle:胆汁酸膜受体TGR5在肝脏代谢免疫中的研究进展
- Author:
Baobing HAO
;
Jianhua RAO
;
Ling LYU
;
Feng ZHANG
- Publication Type:Journal Article
- Keywords:
Bile acid mambrane receptor,TGR5;
Bile acid;
Liver metabolism;
Inflammation;
Liver injury
- From:
Chinese Journal of Hepatobiliary Surgery
2014;20(11):834-837
- CountryChina
- Language:Chinese
-
Abstract:
TGR5,expressing in many tissue cells,is a kind of bile acid membrane receptor and participates in a variety of metabolic and immune diseases.Activated TGR5 can keep the metabolism system in a steady state by mediating the metabolism of bile acid,lipid,and blood sugar,reducing insulin resistance and increasing the body's energy consumption; TGR5 could regulate the immune responses of mononuclear cell and Kupffer cell in the liver.For example,it can regulate the adaptive immune response by inhibiting the expression and release of inflammatory cytokines in Kupffer cells,and regulating the differentiation and maturation of dendritic cells.This review mainly focused on the function of TGR5 in liver metabolism and immune and further explored the related mechanism,as well as its clinical significance in related liver diseases.
