S100A8 and S100A9 in autoimmune diseases
10.3760/cma.j.issn.1673-4408.2015.03.008
- VernacularTitle:S100A8和S100A9对自身免疫性疾病影响的研究进展
- Author:
Xiao HU
- Publication Type:Journal Article
- Keywords:
Toll-like receptor;
Receptor for advanced glycation end product;
Autoimmune disease
- From:
International Journal of Pediatrics
2015;42(3):257-260
- CountryChina
- Language:Chinese
-
Abstract:
S100A8 and S100A9 are abundantly expressed in neutrophils cytoplasm,they are calciumbinding proteins and they often exist as S100A8/A9 heterodimer.Previous studies have shown that the biological functions of S100A8 and S100A9 are associated with chronic inflammatory diseases and a variety of cancers.They are important to inflammation by binding and activation Toll-like receptor4 (TLR4) and receptor for advanced glycation end products(RAGE),and mediating intracellular inflammatory signaling transduction.This review summarizes the studies on functions and molecular mechanism of S100A8 and S100A9 in autoimmune diseases,which might propose new strategies for diagnosis,treatment and suggested disease activity.
