Research progress of cell death and therapy in malignant melanoma
10.3760/cma.j.issn.1006-9801.2015.06.018
- VernacularTitle:恶性黑色素瘤细胞死亡与治疗研究进展
- Author:
Xinyuan WANG
- Publication Type:Journal Article
- Keywords:
Melanoma;
Cell death;
Therapy
- From:
Cancer Research and Clinic
2015;27(6):426-429
- CountryChina
- Language:Chinese
-
Abstract:
Malignant melanoma is the most aggressive form of skin cancer and insensitive to almost all clinical cancer therapies.Apoptosis,necrosis,autophagy,senescence and mitotic catastrophe,all of these different manners constitute cell death way.Chemotherapy induces cell death at last by the signal pathway of apoptosis,so the reason for treatment failure of melanoma is the establishment of the mechanism of apoptotic resistance in melanoma cells.This article reviews the death style of melanoma cells and the progress of targeting small molecule drug therapy for malignant melanoma.
