Expression and clinical significance of SIRT1 in hepatocellular carcinoma

VernacularTitle:沉默信息调节因子2相关酶1在肝癌中的表达及临床意义
Author: Zhengyun ZHANG ; Zunqiang ZHOU ; Jiao GUAN ; Hao LI ; Guangwen ZHOU
Publication Type:Journal Article
Keywords: Hepatocellular carcinoma; Silent mating-type information regulation 2 homologue 1; Amp-actived protein kinase
From: Chinese Journal of Hepatobiliary Surgery 2014;20(11):790-794
CountryChina
Language:Chinese
Abstract: Objective To investigate the clinical significance of silent mating-type information regulation 2 homologue 1 (SIRT1) in hepatocellular carcinoma (HCC).Method We analyzed p53 mutation by gene sequencing and activation of SIRT1 and AMP-actived protein kinase (AMPK) using western-blot in 252 patients with hepatitis B virus-positive HCC.Results A higher proportion of tissues with mutant p53 were demonstrated to harbor activated SIRT1 (64.8％ vs 31.8％ ; P ＜ 0.01).Activated SIRT1 predicted a longer relapse-free survival.On multivariate analysis,activated SIRT1 remained significant (OR:0.339,CI:0.160-0.720,P =0.005).Analysis of 252 paired specimens revealed a significant correlation between activated SIRT1 and activated AMPK in HCC tissues harboring mutant p53 (P =0.007).Conclusion SIRT1 exerted anti-carcinogenic effects through the AMPK pathway in HCC in the context of mutant p53.