The changes and clinical significance of DKK1 level before and after treatment in primary liver cancer
10.3760/cma.j.issn.1008-6706.2015.02.027
- VernacularTitle:原发性肝癌介入治疗前后DKK1表达水平的变化及临床意义
- Author:
Jun YAO
- Publication Type:Journal Article
- Keywords:
Carcinoma,hepatocellular;
Glycoproteins
- From:
Chinese Journal of Primary Medicine and Pharmacy
2015;22(2):238-240
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the changes and clinical significance of DKK1 level before and after treatment in primary liver cancer.Methods 120 cases with primary liver cancer were selected as the study group,120 healthy people were selected as the control group.The serum level of DKK1 before and after treatment was detected by enzyme-linked immunosorbent assay (ELISA),and its relationship with clinical features was analyzed.Results Before treatment,the serum level of DKK1 in the study group was (54.2 ± 1.8) pg/mL,which was significantly higher than (25.8 ± 2.4) pg/mL in the control group (t =10.692,P =0.024).The level of DKK1 had relationship with tumor capsule,hilar lymph node metastasis,TNM stage and vascular invasion (x2 =12.528,11.792,14.829,13.078,P =0.024,0.028,0.015,0.019) ; The level of DKK1 in the first day after interventional treatment was (53.9 ± 1.3) pg/mL,which had no statistically significant difference compared with before treatment(t =6.038,P =0.075) ; 7 days and one month after treatment,the DKK1 levels were (35.2 ± 1.5) pg/mL and (28.9 ±0.32) pg/mL,which were significantly lower than those before treatment (t =9.056,10.639,P =0.019,0.017).Conclusion Before treatment,the serum DKK1 level is contribute to the diagnosis of hepatocellular carcinoma,and related with clinical characteristics,DKK1 level significantly decreased after treatment,which can help in evaluating the therapeutic effect.
