Genetic mechanisms of intravenous immunoglobulin resistance in Kawasaki disease

VernacularTitle:静脉注射丙种球蛋白无反应型川崎病遗传学进展
Author: Cuizhen ZHOU
Publication Type:Journal Article
Keywords: Kawasaki disease; Intravenous immunoglobulin resistance; Polymorphisms
From: International Journal of Pediatrics 2015;42(2):199-202
CountryChina
Language:Chinese
Abstract: Kawasaki disease(KD)has been the leading cause of acquired heart disease in children.Treatment with high dose intravenous immunoglobulin(IVIG) is effective,but about 10％ to 20％ KD patients have no response to initial IVIG treatment.These patients always show persistent or recurrent fever after completion of IVIG,and have a particularly high risk of developing coronary artery lesions.Recent studies have showed that there was some relationship between genetic polymorphisms and IVIG resistance.The genetic polymorphisms of IgG-Fc region receptors and inositol 1,4,5-trisphosphate 3-kinase C have been well studied and showed significant relationship with IVIG resistance in KD.Here,we provide an overview of recent genetic studies of IVIG resistant KD.