Research progress on the molecular mechanism of breast cancer bone metastasis
- VernacularTitle:乳腺癌骨转移分子机制研究进展
- Author:
Huijuan ZENG
;
Shaohua WANG
- Publication Type:Journal Article
- Keywords:
Breast cancer bone metastases;
Molecular mechanism;
Animal models
- From:
Journal of Medical Postgraduates
2015;(4):432-436
- CountryChina
- Language:Chinese
-
Abstract:
Breast cancer is one of the most common malignant tumors in women. Bone is commonly affected in the context of metastatic breast cancer.Once bone metastasis happens, patient would experience poor prognosis and impaired quality of life.However, there is a lack of approaches for more sensitive and specific diagnosis and treatments for breast cancer bone metastasis.Thus, it is im-perative to find new treatment target from molecular mechanism.In this paper, we review the current research progress on the molecular mechanism from several levels including gene profile, proteins and microRNAs.We also review the establishment of animal models of breast cancer bone metastasis.With the achievements acquired in the completed or undergoing researches on breast cancer bone metasta-sis, we hope the finding of the optimal diagnostic and therapeutic targets could lead the breast cancer research into a new era.
