Autoantigens in type 1 diabetes
10.3760/cma.j.issn.1673-4408.2015.02.019
- VernacularTitle:1型糖尿病自身抗原研究进展
- Author:
Shuang ZHAI
- Publication Type:Journal Article
- Keywords:
Type 1 diabetes;
Chromogranin A;
Islet amyloid polypeptide;
Zinc transporter 8;
Pancreatic duodenal homeobox factor-1
- From:
International Journal of Pediatrics
2015;42(2):185-189
- CountryChina
- Language:Chinese
-
Abstract:
Autoimmunity is the main mechanism of type 1 diabetes.The discovery of autoantigens has broadened our understanding of pathogenesis and clinical diagnosis of type 1 diabetes.Insulin,glutamic acid decarboxylase 65,and insulinoma-associated protein 2 have been found to be major autoantigens of type 1 diabetes.In recent years,some autoantigens in type 1 diabetes,such as chromogranin A,islet amyloid polypeptide,zinc transporter 8,and pancreatic duodenal homeobox factor-1,have received some attention in the literature.The purpose of this article is to review the progress of novel autoantigens in type 1 diabetes.
