Analysis of 28 cases with drug-induced hypersensitivity syndrome

VernacularTitle:药物超敏反应综合征28例分析
Author: Xiaobin MENG ; Caihong QU
Publication Type:Journal Article
Keywords: Drug-induced hypersensitivity syndrome; Allopurinol; Antiuberculotic drugs; Anti-epileptic drugs; Non-steroidal anti-inflammatory drugs
From: Chinese Journal of Primary Medicine and Pharmacy 2015;22(2):226-228
CountryChina
Language:Chinese
Abstract: Objective To investigate the pharmacoepidemiologic features of drug-induced hypersensitivity syndrome (DHS) and improve the recognition of its particularity.Methods The clinical data of 28 patients with DHS were retrospectively analyzed and summarized.Results Of 28 DHS patients,the suspected drugs were allopurinol in 17 cases,anti-epileptic drugs in 4 cases,antiuberculotic drugs in 3 cases and non-steroidal anti-inflammatory drugs in 4 cases.The earliest symptoms of DHS were skin rash (89.3 ％) and fever(85.7 ％),secondly liver function damaged(75.0％),which may be accompanied by mucosa,eye,genital damage (53.6％),eosinophilia (32.1％),renal impairment (17.9％),even multiple organ failure and death.Conclusion DHS should be on the alert when rash,repeated fever and visceral lesion occurred in a patient,without good therapeutic efficacy through ordinary anti-anaphylaxis and anti-infective therapy,as well as with the above medication history.