Mechanism of reducing ischemia-reperfusion injury in orthotopic liver transplantation retrograde perfusion method
10.3760/cma.j.issn.1007-8118.2014.10.022
- VernacularTitle:原位肝移植逆行灌注法减轻肝脏缺血再灌注损伤的作用机制
- Author:
Sirun LI
;
Yi JIANG
- Publication Type:Journal Article
- Keywords:
Liver transplantation;
Liver disease;
Retrograde perfusion
- From:
Chinese Journal of Hepatobiliary Surgery
2014;20(10):765-768
- CountryChina
- Language:Chinese
-
Abstract:
Since 1950s,the idea of liver transplantation (LT) was proposed,the technique of LT had been gradually and widely applied in the field of surgery.The development of LT experienced three stages,including animal experiment,clinical probation and clinical application.It is well known that LT is the only effective therapeutic method for terminal stage of liver diseases.In liver transplantation,the ischemia-reperfusion injury is difficult to avoid,and an important factor causing poor liver function.Meanwhile,hemodynamic volatility and internal environment disorder are important prognostic factors.How to reduce ischemia-reperfusion injury of the transplanted liver and improve intraoperative hemodynamic changes in liver transplantation is a clinical research focus.Recent studies has indicated that orthotopic liver transplantation retrograde perfusion method can effectively reduce the transplanted liver ischemia-reperfusion injury and improve liver function early after transplantation,and thus significantly improve the success rate of liver transplantation and survival.
