A review on the gene of CRLF2 in childhood B-cell precursor acute lymphocytic leukemia
10.3760/cma.j.issn.1673-4408.2015.02.013
- VernacularTitle:CRLF2基因在儿童B系急性淋巴细胞性白血病中的研究进展
- Author:
Min JIANG
- Publication Type:Journal Article
- Keywords:
Cytokine receptor-like factor 2 gene;
Acute lymphocytic leukemia;
Children
- From:
International Journal of Pediatrics
2015;42(2):163-166
- CountryChina
- Language:Chinese
-
Abstract:
Current risk classification in childhood B-cell precursor acute lymphocytic leukemia has been used to modulate the intensity of treatment and prognosis assessment.However there are a significant proportion of relapses and deaths occur among childhood with good risk clinical characteristics and/or an excellent early response to therapy.So research about the aberrant expression of gene associated with relapse will improve cure rate.Aberrant expression of CRLF2 gene can be found in childhood B-cell precursor acute lymphocytic leukemia and associated with JAK aberrantion,BCR-ABL1-like signature,IKZF deletion.Over-expression of CRLF2 gene is associated with high risk relapse and poor outcome in childhood B-cell precursor acute lymphocytic leukemia,but its prognostic value is still controversial.This article mainly reviews the progress of CRLF2 gene in childhood B-cell precursor acute lymphocytic leukemia.
