The role of atrial natriuretic peptide and endothelin 1 on congenital heart failure of newborns
10.3760/cma.j.issn.1008-6315.2014.09.002
- VernacularTitle:新生儿先天性心脏病心力衰竭与内皮素1和心房利钠肽的关系
- Author:
Jiahua LU
;
Yongqiang FENG
- Publication Type:Journal Article
- Keywords:
Newborns congenital heart disease;
Heart failure;
Heart defects;
Endothelin 1;
Atrial natriuretic peptide
- From:
Clinical Medicine of China
2014;30(9):901-903
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the role of atrial natriuretic peptide(ANP) and endothelin 1 (ET-1) of newborns with congenital heart failure and its clinical significance.Methods One hundred newborns with congenital heart disease were selected as our subjects.They were divided into 3 groups according to cardiac function grading criteria and that were grade Ⅰ group(30 cases),grade Ⅱ group(40 cases) and grade Ⅲ-Ⅳ group(30 cases).Another 30 normal newborns were served as control group matched with age,gender.ET-1,ANP were detected.Results The levels of ET-1 and ANP in newborns of grade Ⅲ-Ⅳ were (132.35 ±5.26) ng/L and (9.25 ± 2.37) pmol/L,significant higher than that in control group((53.62 ± 3.81) ng/L and (1.15 ±0.09) pmol/L;P ＜0.01).As the severity of the disease in newborns with congenital heart failure,the level of ET-1,ANP were activated more.There was a positive correlation between ET-1 and grade of cardiac function (r =0.35,P ＜ 0.01).Meanwhile,it also showed a positive correlation between ANP and cardiac function (r =0.72,P ＜ 0.01).Conclusion ET-1,ANP in newborns with congenital heart disease are activated with characterized of chronic heart failure,and related to severity of the disease.
