The Laboratory Monitoring of Aspirin Therapy in Perioperative Patients with General Surgery
10.3969/j.issn.0253-9896.2013.09.007
- VernacularTitle:普外围手术期患者应用阿司匹林的实验室监测
- Author:
Jing REN
;
Jianlong MEN
;
Wei LIU
;
Bowei ZHANG
;
Rui MA
- Publication Type:Journal Article
- Keywords:
arachidonic acid;
platelet aggregation;
ASPIRIN;
intraoperative period;
platelet agglutination rate test;
11-dehydro-thromboxane B2
- From:
Tianjin Medical Journal
2013;(9):871-874
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the reasonable time limit for stopping the aspirin treatment in preoperative pa-tients with general surgery and the effects on platelet function in postoperative patients with recovering the therapy of aspirin. Methods A total of 121 patients undergoing elective general surgery were divided into stopping aspirin treatment 5 d group (n=59) and stopping aspirin treatment 7 d group (n=62). Fifty healthy volunteers were used as the control group. The arachi-donic acid (AA)-induced platelet aggregation test was used to detect the platelet agglutination rate in all groups. Aspirin was reused 24~48 h after surgery. The level of urinary 11-dehydro-thromboxane B2 (11-DH-TXB2) was assayed by ELISA 7 and 10 d after retreatment. Results The levels of the PAgT (5 min, 8 min and 10 min) were decreased significantly in pa-tients with stopping aspirin treatment 5 d group compared with those of patients with stopping aspirin treatment 7 d group and control group (P<0.05). There was no significant difference in the level of PAgT between patients with stopping aspirin treatment 7 d group and control group. The platelet aggregation showed two different characteristic curves after stopping aspi-rin treatment for 5 d. And the normal curve of platelet aggregation was found after stopping aspirin treatment for 7 d. The lev-els of PAgT and urinary 11-DH-TXB2 were significantly lower in patient recovered the aspirin treatment for 7 d and 10 d than that of control, and which was significantly higher in 7 d group than that of 10 d group (P>0.05). Conclusion The platelet aggregative function returned to normal level in patients with 7-d preoperative stopping aspirin. The laboratory moni-toring of aspirin therapy should be more than 7 d after postoperative reusing aspirin.
