Research progress in role of nuclear factor E2-related factor2 in regulating development of cirrhotic portal hypertension
10.3760/cma.j.issn.1007-8118.2015.02.018
- VernacularTitle:核因子-E2相关因子2与门静脉高压症相关血管活性递质的研究进展
- Author:
Yue HE
;
Meng LUO
- Publication Type:Journal Article
- Keywords:
Liver cirrhosis;
Hyperdynamic circulation;
Nuclear factor E2-related factor2
- From:
Chinese Journal of Hepatobiliary Surgery
2015;21(2):137-140
- CountryChina
- Language:Chinese
-
Abstract:
Cirrhotic portal hypertension is associated with both increased intrahepatic vascular resistance and hyperdynamic circulation.These two pathogical changes of portal hypertension can be contributed to the unusually high or unusually low levels of vasodilator in liver and splanchnic organs.Vascular hyporesponsiveness due to reactive oxygen species is also a key factor which accounts for portal hemodynamic abnormalities.Transcription factor nuclear factor E2-related factor 2 (Nrf2),known by its role in anti-oxygenation,can initiate and enhance transcription of antioxidant response element (ARE) when exposure to oxidative stress occures.Related influence on expression of nitric oxide,carbon monoxide and their coenzymes has also been demonstrated for decades.The potential clinical significance will be unfolded if changes of Nrf2 expression,as well as the way modulating Nrf2,are found in cirrhotic portal hypertension.
