Corticosteroids treatment in acute respiratory distress syndrome
10.3760/cma.j.issn.1673-4912.2014.12.003
- VernacularTitle:糖皮质激素在急性呼吸窘迫综合征中的应用
- Author:
Qunfang RONG
;
Yucai ZHANG
- Publication Type:Journal Article
- Keywords:
Corticosteroid;
Acute respiratory distress syndrome;
Children
- From:
Chinese Pediatric Emergency Medicine
2014;21(12):756-759
- CountryChina
- Language:Chinese
-
Abstract:
The presence and persistence of systemic and lung inflammation in children with acute respiratory distress syndrome (ARDS) is the basis for the use of corticosteroids as a therapeutic agent.The trial of ARDS treated with high-dose short-course corticosteroids showed no benefit,even increase motality.At present,the results of randomized controlled trial and meta-analysis suggested that low-dose and replacement-dose methylprednisolone [1-2 mg/(kg· d)] or equivalent types of corticosteroids may decrease the fatality rate,reduce staying days in ICU and the duration of mechanical ventilation.Use of corticosteroids for ARDS in children is still lack of multicenter randomized controlled trial.
