Moisture Proof of Membrane-coating Sirolimus Dropping Pills
- VernacularTitle:薄膜包衣西罗莫司滴丸防潮性考察
- Author:
Shaoting LI
;
Wen HE
;
Xianxi GUO
;
Ling SONG
- Publication Type:Journal Article
- Keywords:
Sirolimus;
Droppingpills;
Membranecoating;
Moistureproof
- From:
China Pharmacist
2014;(10):1677-1679
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To coat sirolimus ( SRL) dropping pills with a membrane to enhance the ability of moisture proof. Meth-ods:Opadry was chosen as the coating material. The solvent, concentration and weight gain of the coating membrane were defined, and the coating parameters were screened. The critical relative humidity ( CRH%) of membrane-coating SRL dropping pills was detec-ted and compared with that of SRL dropping pills without coating. Results: The formula and coating parameters of membrane-coating SRL dropping pills were as follows:95% ethanol was used as the solvent, Opadry concentration was 6. 5%, the weigh gain was 4%, the inlet air temperature was (35 ± 2)℃, the inlet fluid rate was 12 ml·min-1 and the spraying pressure was 3. 0 MPa. The CRH%of memebrane-coating SRLs dropping pills was 63. 1%, which was much higher than that of uncoated SRL dropping pills (36. 1%). Conclusion:The membrane-coating can enhance the moisture proof of SRL dropping pills, which is beneficial to the stability.
