Rationality Analysis of Thimerosal Content in Chloramphenicol Eye Drops
- VernacularTitle:氯霉素滴眼剂处方中硫柳汞含量的合理性分析
- Author:
Jiheng LIN
;
Huang XIAO
;
Wansheng CHEN
;
Shihong MA
;
Changqin HU
- Publication Type:Journal Article
- Keywords:
Chloramphenicoleyedrops;
Antimicrobialeffect;
Thimerosal
- From:
China Pharmacist
2014;(10):1687-1690
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the content rationality of antimicrobial agent thimerosal in chloramphenicol eye drops. Meth-ods:Chloramphenicol eye drops with thimerosal at different concentrations were prepared, and the antimicrobial activity was studied. Results:When the test solution contained 0. 02 mg·ml-1 thimerosal, the antimicrobial activity could achieve the requirement in the pharmacopoeia. Conclusion:Thimerosal at different concentrations in the commercial chloramphenicol eye drops all can reach the anti-microbial effect. However, the thimerosal concentration in some eye drops is unreasonably high, which should be reduced.
