Curative Effect of r IL-2 Combined with Cisplatin in the Treatment of Patients with Malignant Pleural Ef-fusions
- VernacularTitle:人重组白介素2联合顺铂治疗恶性胸腔积液的临床疗效观察
- Author:
Lijie HE
;
Qiuju YU
;
Ziying WANG
- Publication Type:Journal Article
- Keywords:
Cisplatin;
rIL-2;
Malignantpleuraleffusion
- From:
China Pharmacist
2014;(10):1698-1699
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the curative effect and adverse reactions of cisplatin combined with rIL-2 on malignant pleural effusion. Methods:Totally 60 cases of patients with malignant pleural effusion were randomly divided into the observation group ( 30 cases) and the control group (30 cases). In the observation group, 30 cases were given intrapleural injection of cisplatin and rIL-2 af-ter the pleural effusions were drained, and in the control group, the patients received intrapleural injection of cisplatin. Both of the two groups were observed of tumor response and drug adverse reactions, compared the quelity of life and immune function indicators before and after treatment. Results:The response rate in the observation group was 83. 3%, which was significantly higher than that in the control group (56. 7%) (P<0. 05). The improvement of Karnofsky score in the observation group was 86. 7%, which was also nota-bly higher than that in the control group(63. 3%) (P<0. 05). After the treatment, CD4 level and CD4/CD8 were significantly in-creased in the observation group(P<0. 05), while those in the control group were notably decreased (P<0. 05), and the difference was statistically significant (P<0. 05). The incidence of adverse reactions shew no significant difference between the two groups (P>0. 05). Conclusion:Cisplatin combined with rIL-2 shows confirmed effects in the patients with malignant pleural effusion.
