Vitamin D and systemic lupus erythematosus
10.3760/cma.j.issn.1673-4408.2015.03.014
- VernacularTitle:维生素D与系统性红斑狼疮的研究进展
- Author:
Ming LI
- Publication Type:Journal Article
- Keywords:
Vitamin D;
Systemic lupus erythematosus
- From:
International Journal of Pediatrics
2015;42(3):284-287
- CountryChina
- Language:Chinese
-
Abstract:
Vitamin D is a steroid hormone that exerts its action by binding to the vitamin D receptor.In addition to its actions on calcium and phosphate metabolism,it exhibits a plethora of regulatory effects on proliferation,dfferentation and function of the cells of the immune system,thus play an important role in the regulation of the immune response.Systemic lupus erythematosus (SLE) is a multisystemic auto-Immune disease that is characterized by a number of autoantibodies.VitD and VDR can inhibit the activation of autoreactive lymphocyte and the production of auto-antibodies,thus play an important role in the development and mechanism of SLE.Supplementation of VitD may improve the progrosis of SLE.
