Antibiotic use in early life and childhood asthma:causation or confounding?
10.3760/cma.j.issn.1673-4408.2015.02.004
- VernacularTitle:生命早期抗生素使用与儿童哮喘:因果关系还是混杂效应?
- Author:
Runfang HU
- Publication Type:Journal Article
- Keywords:
Antibiotics;
Asthma;
Early life
- From:
International Journal of Pediatrics
2015;42(2):132-134
- CountryChina
- Language:Chinese
-
Abstract:
The prevalence of childhood asthma has been increased yearly.Based on the hygiene hypothesis,the antibiotic use may increase the risk of the allergic disease by reducing microbial exposure.In the last decade,a number of epidemiological studies have been conducted on the association between early exposure of antibiotic and childhood asthma,and the results are not consistent.The majority retrospective studies have found a positive association but the prospective studies have showed a null or weak association.Reverse causation and confounding-by-indication may partly explain the relation.But it is difficult to deny a causal link between antibiotic use and asthma.
