Roles of miRNAs in HPV-related cancers
10.3760/cma.j.issn.1009-9158.2014.12.026
- VernacularTitle:miRNA在HPV相关肿瘤发生中的作用
- Author:
Shimeng ZHANG
;
Fei LIU
;
Lei ZHENG
;
Qian WANG
- Publication Type:Journal Article
- Keywords:
Papillomaviridea;
microRNAs;
Uterine cervical neoplasms;
Head and neck neoplasms
- From:
Chinese Journal of Laboratory Medicine
2014;37(12):977-981
- CountryChina
- Language:Chinese
-
Abstract:
High-risk human papillomavirus infection is the major cause of tumors such as cervical cancer and head and neck cancer.MicroRNAs (miRNAs) are 20-25nt small non-coding RNAs,which are involved in the proliferation,apoptosis,invasion and migration of tumors.HR-HPVs,which integrate into the host genome,encode three oncogenes:E6,E7 and E5 and enhance carcinogenesis by regulating downstream miRNAs and genes e.g.p53 and pRb.
