Soluble ST2 and its prospects of clinical application in cardiovascular disease
10.3760/cma.j.issn.1009-9158.2014.12.024
- VernacularTitle:可溶性ST2在心血管疾病中的临床应用及展望
- Author:
Hui YUAN
;
Xu MA
- Publication Type:Journal Article
- Keywords:
Myocardial ischemia;
Heart failure;
Receptors,cell surface;
Biological markers
- From:
Chinese Journal of Laboratory Medicine
2014;37(12):969-972
- CountryChina
- Language:Chinese
-
Abstract:
Soluble ST2 (sST2) is a decoy receptor of IL-33 in blood.sST2and ST2L (receptor on cell membrane) seem to be markedly induced in mechanically overloaded cardiac myocytes,especially the expression of sST2.A large number of sST2 bind IL-33 thus subtracting IL-33 from the interaction with ST2L,potentially attenuating the cardioprotective effects of IL-33/ST2L pathway.Recently,sST2 has emerged as a novel for heart failure biomarker.Though sST2 was a less robust marker for the diagnosis of heart failure than NT-proBNP,it has been implicated in the prognostication of patients with acute dyspnea,acute or chronic heart failure and myocardial infarction,with particular value for mid-and long-term prognosis.However,further studies are needed in order to better point out the evidence for a routine use of sST2 evaluation in patients suffering from cardiovascular diseases.
