Adverse reactions of fludarabine in the treatment of chronic lymphoproliferative disorders
10.3760/cma.j.issn.1009-9921.2014.03.018
- VernacularTitle:氟达拉滨治疗慢性淋巴细胞增殖性疾病的常见不良反应
- Author:
Ming HONG
- Publication Type:Journal Article
- Keywords:
Fludarabine;
Lymphoproliferative disorders;
Adverse reaction
- From:
Journal of Leukemia & Lymphoma
2014;23(3):182-184
- CountryChina
- Language:Chinese
-
Abstract:
Fludarabine (Flu) is a synthetic purine analog,which has been widely used in the treatment of B-cell chronic lymphoproliferative disorders (B-CLPD) such as chronic lymphocytic leukemia (CLL),nonHodgkin lymphoma (NHL) as an anti-metabolic cytotoxic chemotherapeutic drug and achieved good effect.Main adverse reactions in clinical application of Flu are dose-dependent bone marrow suppression and secondary infection.Non-hematologic adverse reactions are so rare and mild that most patients can tolerate.
